Acute Pharmacological Effects of 2C-B in Humans: An Observational Study PMC
The purpose of the present study is to assess the acute pharmacological effects and oral fluid pharmacokinetics of 2C-B in humans. In September 2000, police officers arrested a 24-year-old Caucasian male resident of Johnson County, Kansas, near a Kansas City nightclub that is popular with users of MDMA and other club drugs. The man, sweating profusely and in need of medical attention, was found to be in possession of 74 white 2C-B tablets. Another interesting side effect, or lack thereof, is that many users also report being able to eat and sleep with ease after the experience—something they’ve struggled with after a night with MDMA or LSD. Plus, at low and moderate doses, many report still being able to perform sexually (and really enjoying it), which is pretty famously hard on MDMA without the help of drugs like Viagra.
Is 2C-B safe?
Groups responsible for producing and distributing 2C-B are largely unknown to law enforcement. Though research for this Information Bulletin did not identify any recent instances of C-B production in the United States, law enforcement authorities in both the United Kingdom and Canada have arrested individuals for manufacturing this drug. In June 2000, officials with the Maine Drug Enforcement Task Force in Houlton arrested a Caucasian male for a violation of his probation. The 20-year-old was in possession of three pink tablets, 5 millimeters in diameter, with no markings. The subject refused to cooperate with authorities, who have not seen Nexus since that time.
How Does 2C-B Affect Mood and Perception?
In August 2007, 2C-B, along with many other psychologically active substances,[44] was added to Ley 20.000, known as the Ley de Drogas [es]. Nevertheless, the few cases of long-term psychosis attributed to 2C-B are highly questionable, and it’s not known that the drug was even involved. Testing your 2C-B is always good practice even when you trust your supplier. Reagent test kits from Bunk Police can identify hundreds of adulterants and substitutes—offering peace of mind and potentially saving your life. Third Wave’s Ultimate Guide to Sourcing Psychedelic Medicine offers step-by-step instructions for navigating the dark web and recommendations for lesser-known (legal) psychedelic alternatives with similar effects.
Risks And Dangers Of Using Pink Cocaine 2C-B
Public health concerns have arisen regarding pink cocaine 2C-B, one of several names for a novel synthetic drug that has been populating rave culture and earning a high-risk reputation. Detailed, evidence-based information on drugs and their properties, applications, effects and risks. Recovered is not a medical, healthcare or therapeutic services provider and no medical, psychiatric, psychological or physical treatment or advice is being provided by Recovered. If you are facing a medical emergency or considering suicide or self harm, please call 911 immediately. The hallucinogenic properties of 2C drugs can cause a distorted sense of reality as well as dissociation and hallucinations, similar to ketamine.
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2C-B intoxication may also lead to a state of excited delirium, which involves violence, agitation, hypertension, tachycardia, and hyperthermia. Regarding the effects measured with the ARCI questionnaire, after 2C-B administration significant changes in all ARCI subscales were observed, expect for PCAG (sedation). The most new life house marked increases compared to baseline were found for MBG (euphoria) and A (amphetamine) subscales. Modest increases were detected for LSD (dysphoria and somatic symptoms) and BG (intellectual efficiency and energy) subscales. 2C-B produced robust changes in most subjective effects measured by VAS, ARCI, and VESSPA-SEE.
Law enforcement agencies concerned with club drug distribution and abuseshould consider 2C-B a potential drug threat. Due to the broad range ofdose-dependent effects, law enforcement personnel may encounter users exhibitinga variety of behaviors, from sedation to paranoia. The purpose of this Information Bulletin is to inform the law enforcement and treatment communities about the reappearance alcohol use disorder diagnosis and treatment of 2C-B (Nexus) on the club drug scene. The subject areas covered include what 2C-B is, method of use, cost, appearance, doses and effects, potential side effects, identification, and history of the drug. 2C-B is one of the most popular psychoactive substances globally — despite there being virtually no research available on its safety or effect profiles in the medical literature.
How are 2C drugs taken?
- Certain poly-drug mixes can increase risks, and it is not advised to mix MAOI antidepressants, lithium, or tramadol with 2C-B.
- Though part of the same family of compounds, 2C-B isn’t the same as 2C-P, the more dangerous drug implicated in the death of Louella Fletcher-Michie at Bestival in 2017.
- There’s also been reports of numerous darknet dealers selling 2C-B as MDMA.
- Our results showed the highest scores for intensity, volition and affect subscales.
- According to PiHKAL, 2C-B lasts between four and eight hours, and that’s pretty in line with what the 31 people who took my survey reported.
- This is because long-term use can result in drug dependence, with a certain dose of the substance required for the body to function normally.
It was also briefly marketed as an aphrodisiac in the U.S. and the Netherlands before it was made illegal in 1995. Read here to learn more about how long other drugs stay in your system. According to DEA research, a single pill of 2C-B has a street price of between $10 and $30 and a gram of powder can be purchased online for between $100 and $300. Mixing drugs is always risky but some mixtures are more dangerous than others. As hallucinogens, they can make you experience reality in a distorted way that may cause hallucinations (seeing and hearing things that aren’t there).
Visit the following websites to learn about The Recovery Village’s network of rehabilitation facilities. Each center is ready to help people learn how to cope with their addiction and uncover the root causes for their substance use disorder. Unlike MDMA, it doesn’t deplete serotonin, the chemical in our bodies that tells us to be happy. Instead, it mimics it – in the same way as certain antidepressants – meaning sad thoughts and exhaustion after use, along with long-term damage to brain cells (neurotoxicity), aren’t as likely.
However, quitting 2C-B gradually may be advisable if the drug has been used for a long duration. This is because long-term use can result in drug dependence, with a certain dose of the substance required for the body to function normally. Quitting suddenly may result in severe adverse effects, so consulting with a medical professional can help you or a loved one detox safely. Although there are no established guidelines for the treatment of 2C-B addiction, an evidence-based approach for the treatment of addictions, in general, may be necessary for detoxification. Melatonin supplements at normal doses appear to be safe for most children for short-term use, but there aren’t many studies on children and melatonin.
SFPD officials stated that this was their first encounter with 2C-B. All in all, this novel psychoactive substance that the Shulgins were so fond of seems to have a lot of potential if used in a safe and intentional manner, but more research is sorely needed. But unlike MDMA, which may leave some feeling the famous “serotonin dump” hangover the next day, 2C-B is a bit different.
With that said, hangovers are still possible — and are especially common with the higher doses. Of the survey respondents that too more than 35 mg of 2C-B, nearly 28% of them had a hangover the following morning. Sometimes 2C-B can feel a little bit “speedy” or “tweaky” — especially in the higher doses. Most of the responses we’ve received throughout our 2C-B survey had a positive sentiment. Many people taking part in our surveys and in the psychedelic community at large consider 2C-B to be their favorite psychedelic. Everybody has heard of MDMA (ecstasy) and LSD (lysergic acid diethylamide) — they’ve become staples in the world of mind-altering substances.
Some report feeling happy and in tune with their surroundings, experiencing introspective thoughts and increased empathy. 2C-B is a Schedule I drug with alcohol intervention no accepted medical drug use and a high potential for addiction. Possession of 2C-B is punishable by up to 7 years in prison, a fine, or both.
Such novel psychedelics include the 2C-series and its structural analogs, including N-Benzylphenethylamines (NBOMes) (Tracy et al., 2017). 2C-series, also called 2C-drugs/compounds, are a related group of substances with presumably psychedelic and psychostimulant properties. All of them are phenylethylamine derivatives structurally close to mescaline with methoxy substitutions at the 2 and 5 positions derived from the two carbon molecules between the benzene ring and the amino group. 2,5-dimethoxy-4-bromophenethylamine (2C-B, Nexus) is one of the oldest and best known 2C-type drugs.
Lower doses of 2C-B are the most similar to MDMA for creating a greater sense of connectedness with the people around you. Both substances produce a feeling of euphoria, can enhance the enjoyment of music, and stimulate the sensual feedback from touch. 2C-B is a stimulant and hallucinogen and can negatively impact one’s physical health and well-being. People often take it with other psychedelic drugs, increasing the probability of addiction and even death. Because 2C-B is illegal and produced in secret laboratories, these illicit drugs are often laced with other substances, causing significant physical and mental risks.
Mixing 2CB with other psychedelics like LSD, mescaline, or magic mushrooms can lead to much stronger hallucinations. The 35 mg dose is a potent psychedelic — and very high doses (50 mg or more) are profoundly psychedelic and have even been known to induce out-of-body experiences. In smaller doses these effects are limited, but higher doses of 2C-B produce intense changes in sensory perception. Users often report feelings of introspection, ego-dissolution, and a stronger sense of empathy and connection with others. It’s not uncommon for people using 2C-B to come to some sort of “realization” about their life. This realization may remain after the trip, but it may also be forgotten.
Compulsive use of any substance would be an example of having an unhealthy relationship with the substance. It’s wise to avoid any other substances while taking 2C-B to avoid negative interactions. One of the main benefits of 2C-B over MDMA is that users usually don’t experience difficulty falling asleep after the experience. The intensity of effects from 2CB increases steadily along with the dose. When various government regulators started banning 2C-B, they did so by banning the entire 2C-x family — as defined by the chemical structure above. 2C-B can also be vaporized — but this isn’t a common way of using it, and the long-term health effects of taking 2C-B this way aren’t well understood.
By contrast, collection of oral fluid is easy and non-invasive, and was the method selected to obtain pharmacokinetic data in this study. Anecdotally, in two subjects involved in a road accident, 2C-B has been identified in blood at concentrations of 1.6 and 14 ng/ml together with amphetamine (Busardò et al., 2017). Because 2C-B is clandestinely produced, users are unaware of the dose theyare ingesting and may be surprised by the drug’s effects.
Studies of the effect of melatonin supplements on cancer symptoms or treatment-related side effects have been small and have had mixed results. Current research looking at the effects of melatonin on COVID-19 is only in the early stages. There are a few randomized controlled trials (studies evaluating melatonin in people) in progress. At this point, it is too soon to reach conclusions on whether melatonin is helpful for COVID-19. There are no overall guidelines on the best approach to improving sleep in children. However, guidelines for specific conditions recommend behavioral treatments, such as good bedtime habits and parent education, as an initial treatment that may be supplemented with medicines.
